Frequency fields (FPolja) use physical forces to disrupt mitosis in cancer cells.
FPolja in the 100 kHz to 500 kHz range disrupt mitosis in cancer cells. Electric forces act on polar cellular components, interfering, for example, with the assembly of structures essential to cell division. Disrupting these structures leads to cell death.
METAPHASE
FPolja interfere with microtubule formation in cancer cells, resulting in an abnormal mitotic spindle.
ANAPHASE
During anaphase in cancer cells, FPolja disrupt the arrangement of septins at the cleavage furrow. This leads to blebs on the cell membrane, errors in mitosis and uneven chromosome distribution.
TELOPHASE
During telophase and cytokinesis, when cancer cells take on an hourglass shape, polar organelles and macromolecules are pushed toward regions where FPolja are more intense. This process is known as dielectrophoresis.
Watch the video to see how frequency fields disrupt mitosis in cancer cells.
Video player
https://youtu.be/x865pJ-K-yI
Research sources
Preclinical study: Kirson et al. (2004), Disruption of cancer cell replication by alternating electric fields